Objective: Ethical guidelines are designed to ensure benefits, protection and respect of participants in clinical research. Clinical trials must now be registered on open-access databases and provide details on ethical considerations. This systematic survey aimed to determine the extent to which recently registered clinical trials report the use of standard of care and post-trial obligations in trial registries, and whether trial characteristics vary according to setting. Methods: We selected global randomized trials registered on http://www.clinicaltrials.gov and http://www.controlled-trials.com. We searched for intervention (...) trials of HIV/AIDS, malaria, and tuberculosis from 9 October 2004, the date of the most recent version of the Helsinki Declaration, to 10 April 2007. Results: We collected data from 312 trials. Fifty-eight percent (58%, 95% CI = 53 to 64) of trial protocols report informed consent. Fifty-eight percent (58%, 95% CI = 53 to 64) of trials report active controls. Almost no trials (1%, 95% CI = 0.5 to 3) mention post-trial provisions. Most trials measure surrogate outcomes. Twenty percent (20%, 95% CI = 16 to 25) of trials measure patient-important outcomes, such as death; and the odds that these outcomes are in a low income country are five times greater than for a developed country (odds ratio (OR) 5.03, 95% CI = 2.70 to 9.35, p = < 0.001). Pharmaceutical companies are involved in 28% (CI = 23 to 33) of trials and measure surrogate outcomes more often than nonpharmaceutical companies (OR 2.45, 95% CI = 1.18 to 5.09, p = 0.31). Conclusion: We found a large discrepancy in the quality of reporting and approaches used in trials in developing settings compared to wealthier settings. (shrink)

Further examines the sense in which moral judgements are universalizable. Distinguishes between moral and logical theses of universalizability and shows how the moral does not follow from the logical. Universalizability, in the form maintained in this book, is a logical, not a moral, thesis; furthermore, nothing substantially moral follows from the logical thesis. The chapter presents the exact import of the thesis and considers the role of moral principles.

Introduces the main themes of the book and expresses the basic conflict between freedom and reason.

Discusses two main uses of pronouns—anaphoric and demonstrative. These pronouns can belong to an intelligible sentence even if they have no referent, so they vindicate the thesis of RWR. A test for intelligibility is that we can correctly report indirect speech in which such a pronoun is used, replacing the original speaker’s demonstrative pronoun by an anaphoric one. For example, a hallucinator’s utterance of ’That little green man is bald’ can be reported as ‘Hallucinating a little green man, she said (...) that he was bald’. (shrink)

In this paper, I argue for the modest claim that people's apparent indifference to animal pain may not be predicated upon speciesism. I defend that claim by developing an analogy between current attitudes toward at least some non‐human animal pain — that which pigs endure while having their tails ‘docked’— and our culture's indifference to the pain that male human infants experience while being circumcised. And I conclude that to convince more of their philosophical and social critics, ‘animal liberationists’ need (...) to spend more time analyzing the pain that non‐human animals experience and defending its moral significance, rather than assuming that such pain is significant and then simply arguing that unnecessary forms of it exist. (shrink)

In list-method directed forgetting, reexposure to forgotten List 1 items has been shown to reduce directed forgetting. proposed that reexposure to a few List 1 items only during a direct test of memory reinstates the entire List 1 episode. In the present experiments, part-list reexposure in the context of indirect as well as direct memory tests reduced directed forgetting. Directed forgetting was reduced when 50% or more of the items were reexposed, and was intact when only 25% were reexposed. Furthermore, (...) part-list reexposure appeared to reinstate only reexposed items-not the entire List 1 episode. (shrink)

Informed by the critical humanisms of Hannah Arendt, Frantz Fanon, and Paul Gilroy, the authors argue for an orientation to teaching and learning that troubles the continuing effects of dehumanizing race logic. Reflecting on Paul Haggis's Oscar award winning film Crash from 2004, they suggest that the metaphor of racial 'crashing' captures what happens when we act out from experiences of racial injury instead of being touched by it. They propose a psychoanalytic pedagogy of emotions as a method for reading (...) representation beyond the limits of detached rational critique. Learning from the affect of racial injury as it is made manifest in representation, they suggest, is an important ethical starting point for generating new insights into what it might mean to live within and beyond contemporary legacies of racial hatred. (shrink)

We argue that thoughts are structures of concepts, and that concepts should be individuated by their origins, rather than in terms of their semantic or epistemic properties. Many features of cognition turn on the vehicles of content, thoughts, rather than on the nature of the contents they express. Originalism makes concepts available to explain, with no threat of circularity, puzzling cases concerning thought. In this paper, we mention Hesperus/Phosphorus puzzles, the Evans-Perry example of the ship seen through different windows, and (...) Mates cases, and we believe that there are many additional applications. (shrink)